How do you counsel patients who want to understand why sublingual cyclobenzaprine works to relieve their fibromyalgia pain and other related symptoms?   

I like to set the stage with patients and make sure they clearly understand the link between sleep disruption and pain sensitivity, particularly in the context of central pain and fibromyalgia. One of my rheumatology attendings during fellowship used to explain this using classic sleep research fro...

Any discussion of pharmacotherapy needs to be grounded in real-world expectations as above: these meds may help some patients, some of the time, but usually as part of a multimodal approach centered around overall wellness. Mechanistically, TCAs are potent SNRIs and influence pain through multiple p...

Based on studies done for the approval of SL cyclobenzaprine, improved sleep duration and sleep quality may help to decrease pain and decrease daytime lethargy. SL cyclobenzaprine, due to SL delivery, bypasses first-pass metabolism, leading to higher serum cyclobenzaprine at night, and lower levels ...