How do you counsel patients with cognitive decline due to Alzheimer's with an indication for anticoagulation (e.g., for atrial fibrillation) who ask about potentially ceasing anticoagulation therapy in order to become a candidate for monoclonal anti-amyloid therapy?

For patients with early Alzheimer's and AF requiring anticoagulation who want anti-amyloid therapy, what do you usually recommend?

• Continue anticoagulation and forgo anti-amyloid therapy
• Evaluate for LAA occlusion to permit anti-amyloid therapy
• Pursue anti-amyloid therapy while continuing a DOAC
• Stop anticoagulation without LAA occlusion to pursue anti-amyloid therapy
• Other