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How do you decide between neoadjuvant chemotherapy vs neoadjuvant radiation in a patient with endometrial cancer not amenable to surgical resection due to cervical involvement?

NCCN offers both EBRT +/- brachytherapy OR systemic therapy as options.
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For endometrial cancer involving the cervix that is precluding surgical resection, do you generally recommend neoadjuvant chemotherapy or radiation?

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2 Answers
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Gynecologic Oncology · Cooper Medical School of Rowan University
Answered on

I'm not sure I have a perfect answer. For this case, the NCCN gives the following recommendations:

-For suspected cervical involvement for patients who are not suitable for primary surgery, EBRT and brachytherapy are effective treatments (category 2A). If the patient is deemed operable 4-12 weeks po...

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Mednet Member
Mednet MemberInvited Expert
Gynecologic Oncology · University of Alabama at Birmingham
Answered on

There are very few tumors with cervical involvement that cannot be resected with a radical hysterectomy (or extrafascial hysterectomy with upper vaginectomy). I have given neoadjuvant chemotherapy or chemotherapy plus IO in cases with extensive vaginal involvement at the time of diagnosis. I general...

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