How do you decide between RPLND vs. chemotherapy in patients with Stage IIA mixed germ cell tumor as primary treatment?
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Do the primary components of a non-seminoma GCT influence your choice of therapy in clinical stage IIA disease?
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3 Answers
Mednet MemberInvited Expert
Medical Oncology · Indiana Univ Simon Cancer Center
Answered on
I agree but would add a few comments:
- If there is a rising hCG or AFP above normal values, we prefer BEP X 3 rather than RPLND. If the patient > age 50, EP X 4. Also, we consider any AFP < 25 to be “ normal” despite many labs listing 0-8 as their normal range.
- Our group recently published data in J...
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Mednet MemberInvited Expert
Medical Oncology · Testicular Cancer Commons
Answered on
CSIIA nonseminoma is not as straightforward as many people think although it is a common clinical scenario in the days of active surveillance in CSI GCTs. A very germane aspect is that probably 20% of clinical IIA GCTs are false positive (when confirmed by pathologic assessments) which means if you ...
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Mednet MemberInvited Expert
Medical Oncology · University of Michigan Medical School
Answered on
If there is teratoma in primary testis cancer and markers are not elevated then prefer RPLND.
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