How do you define bulky disease for Hodgkin's lymphoma which is outside the mediastinum?

Definition of bulk in lymphoma is not homogenous among countries, study groups, and diseases.

Overall, 10 cm is considered the cutoff by some. Recently, the cutoffs of 7 or 7.5 cm have been introduced, especially in DLBCL.

The definition tends to be disease-specific sometimes, since landmark studies ...