How do you determine dose for prostate SBRT?
Is there a dose response relationship, as suggested in the phase I MSKCC dose escalation study presented at ASTRO 2017?
2 Answers
Mednet MemberInvited Expert
Radiation Oncology · NYU Langone
Answered on
The Stanford experience published by King et al was an important one describing a prospective experience of SBRT at dose levels of 35-36.25 Gy, and these dose levels were used based upon prior single institution retrospective reports from community practice settings where a good deal of experience ...
Join for free or sign in to see the full answer
Mednet MemberInvited Expert
Radiation Oncology · Cleveland Clinic
Answered on
The King analysis of over 1,100 patients from multi-center phase II studies is currently the strongest evidence setting the bar at 35-40 Gy in 5 fractions, with no evidence of a dose-response in biochemical outcomes over this range. Most modern SBRT reports fall within this range, and the RTOG/NRG s...
Join for free or sign in to see the full answer