How do you determine dose for prostate SBRT?

Topics: Radiation Oncology • Genitourinary Cancers • Stereotactic Body Radiotherapy • Prostate Cancer

Is there a dose response relationship, as suggested in the phase I MSKCC dose escalation study presented at ASTRO 2017?

Answer from: Radiation Oncologist at Academic Institution

The Stanford experience published by King et al was an important one describing a prospective experience of SBRT at dose levels of 35-36.25 Gy, and these dose levels were used based upon prior single institution retrospective reports from community practice settings where a good deal of experience ...

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Radiation Oncologist at Beth Israel Deaconess Medical Center/Harvard Medical School
The data as reported by Meier et al in this months...

Answer from: Radiation Oncologist at Academic Institution

The King analysis of over 1,100 patients from multi-center phase II studies is currently the strongest evidence setting the bar at 35-40 Gy in 5 fractions, with no evidence of a dose-response in biochemical outcomes over this range. Most modern SBRT reports fall within this range, and the RTOG/NRG s...

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