How do you determine when to transition off pegloticase to other uric acid lowering therapies?

When to transition patients off of pegloticase is a question that is frequently posed to me by my colleagues and by my patients. Pegloticase is not a drug meant for long-term therapy but rather to achieve specific targeted clinical outcomes. I usually recommend once those outcomes are achieved, that 1 to 3 additional infusions be administered after which I transition the patient to oral uric acid lowering drugs.

Pegloticase for gout has provided extraordinary benefits to patients with the most s...