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How do you dose concurrent chemotherapy with once daily radiation for bladder preservation in urothelial carcinoma?

The recommended concurrent chemotherapy regimens (cisplatin/paclitaxel and cisplatin/FU) in NCCN are based on BID fractionation of radiation as in RTOG/NRG trials 0233 and 0712. On what data do you base your bladder preservation regimen?
2 Answers
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Radiation Oncology
Answered on

Two contemporary trials which used daily radiotherapy and concurrent chemotherapy are BC2001 and RTOG 0712 with concurrent chemotherapy schedules as below. Other regimens such as platinum alone have been reported on as well.

BC2001:

  • 5FU: 500mg/m²/d d1-5 & d16-20
  • MMC: 12mg/m² d1
  • Rationale: The study...

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Mednet Member
Mednet MemberInvited Expert
Radiation Oncology · Varian Medical Systems/Allegheny health network
Answered on

There is data on 5FU (day 1 and 21) and MMC (day 1) and also weekly gemcitabine with once-a-day RT.

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