How do you dose concurrent chemotherapy with once daily radiation for bladder preservation in urothelial carcinoma?

Two contemporary trials which used daily radiotherapy and concurrent chemotherapy are BC2001 and RTOG 0712 with concurrent chemotherapy schedules as below. Other regimens such as platinum alone have been reported on as well.

BC2001:

• 5FU: 500mg/m²/d d1-5 & d16-20
• MMC: 12mg/m² d1
• Rationale: The study...

There is data on 5FU (day 1 and 21) and MMC (day 1) and also weekly gemcitabine with once-a-day RT.