How do you explain a very high positive ds-DNA antibody by Elisa but negative by IFA?  

Dr. @Elena Cucurull: I have a similar patient. Her ELISA is > 300 while her IFA is negative. Her ELISA has never fluctuated with disease activity. She ended up getting MALT and lupus myocarditis, making me wonder if the very high anti-dsDNA may have been pathogenic in some way (or at least reflec...