How do you incorporate blinatumomab into therapy for a pediatric or AYA patient with isolated CNS relapse of B-ALL, if at all?
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Do you incorporate blinatumomab into your treatment regimen for pediatric/AYA B-ALL patients with isolated CNS relapse?
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1 Answer
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Pediatric Hematology/Oncology · University of Texas MD Anderson Cancer Center
Answered on
I try to prioritize CAR-T in this setting. Getting there depends on logistics such as financial clearance/collection though. If late relapse or if there is a delay in getting CAR-T, would treat with AALL1331 Arm D (with XRT in mtn), substituting block 3 of blina for block 3 on Arm C (to get more CNS penetrating chemotherapy) or following Dr. Maese's excellent article: Maese and Pulsipher, PMID 37311171.
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