How do you incorporate radiation therapy in patients undergoing CAR T-cell therapy for DLBCL?
2 Answers
Mednet Member
Radiation Oncology · UMass Memorial Medical Group
Answered on · Updated on
It depends on the circumstances of the patient, but there are three emerging indications for RT in the setting of CAR T-cell therapy:
- Tumor debulking prior to CAR T-cell infusion
- Bridging therapy between apheresis and CAR T-cell infusion
- Salvage of refractory, progressive or relapsed disease follow...
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Mednet Member
Radiation Oncology · The University of Texas MD Anderson Cancer Center
Answered on
Radiation can be incorporated with CAR-T in the bridging, consolidative and/or salvage setting.
Bridging radiotherapy benefits patients who present with:
- Rapidly progressive disease that needs to be controlled during the CAR-T manufacturing period (3-6 weeks). Lymphoma at this stage is chemoresistant...
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