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How do you integrate HIV (+) serostatus into a patient's ASCVD if they would not otherwise qualify for a statin either for primary or secondary prophylaxis?

As seen in this published work: Craig Beavers, Alice K. Pau, David Glidden, et al. Statin Therapy as Primary Prevention for Persons With HIV: A Synopsis of Recommendations From the U.S. Department of Health and Human Services Antiretroviral Treatment Guidelines Panel. Ann Intern Med.2025;178:847-857. [Epub 27 May 2025]. doi:10.7326/ANNALS-24-03564
1 Answer
Mednet MemberInvited Expert
Primary Care · Duke Health
Answered on

HIV (+) serostatus is a significant risk-enhancer for the development of cardiovascular disease and should be taken into account when making treatment decisions regarding statin initiation, even if the patient's viral load is low or not detectable. In a patient >40 years old and with a risk >5%, would recommend treatment with at least a moderate-intensity statin for primary prevention given this increased risk. For patients <40 years old or with a risk <5%, consideration of other risk factors (family history, viral load, etc.) will also weigh into the decision-making, not discounting a patient's preference on how aggressive to be with treatment. Additional items that may be considered if statin treatment is not initiated are a more aggressi...

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