How do you interpret and utilize PSA values in patients on dialysis?

There appears to be no clinically relevant impact on total serum PSA, whereas free PSA and % of total can be impacted in a membrane type-dependent manner to where % free PSA is of less utility for screening. Thus, total serum PSA seems reasonable to continue as marker of biochemical control post-treatment and in PCa screening (though of course, this population's competing risks are an argument against routine screening).

Multiple studies have assessed impact of dialysis on total and free serum P...