How do you interpret CSF pleocytosis in the context of significant leukocytosis on CBC?

There is no correction factor as there would be for CSF vs serum glucose, for example. A patient with leukocytosis in peripheral blood, for example, due to urosepsis would not always have elevated CSF WBC unless there were concomitant meningoencephalitis. I would consider 100 WBC abnormal for CSF regardless of serum WBC value, though it would be informative to know the CSF RBC and protein (i.e., was it a bloody/traumatic tap?). In a patient with active AML, I would be concerned about CNS involve...