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How do you interpret discrepancies between MMR testing and MSI testing?

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Mednet Member
Mednet Member
Medical Oncology · Mary Lanning Healthcare Morrison Cancer Center/University of Nebraska Medical Center Adjunct Faculty

Microsatellites are short repetitive sequences of 1 to 6 base pairs of DNA throughout the genome, mostly in noncoding regions. MSI tumors develop through a distinctive molecular pathway characterized by genetic instability in microsatellite DNA repeat sequences. MSI phenotype occurs due to germline ...

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