How do you interpret the results of oligoclonal bands ordered to evaluate for demyelinating disease in patients with brain MRI lesions of unclear etiology?

Topics: Neurology • Neuro-immunology

Does the number of bands matter in making the diagnosis? Does it make a difference whether isolated or also in the serum? How do you interpret other results in this context such as the IgG index, synthesis rate, or others?

Answer from: at Academic Institution

While the presence of oligoclonal bands (OCBs) has been incorporated in the updated diagnostic criteria as a surrogate for dissemination in time, OCBs should not be used in isolation to make the diagnosis of multiple sclerosis. There are several systemic and peripheral immune diseases, including inf...

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