Questions discussed in this category
Do you treat with only an IV steroid pulse or do you use an oral steroid taper as well? How long of a taper do you typically use?
In addition, what formula do you use to calculate the IgG index?
Anecdotally, the diagnostic yield in these patients seems quite low, yet autoimmune encephalitis is often invoked in such patients, particularly in th...
If a patient has classic TM symptoms but a normal MRI, are there specific causes you look for?
How do you approach low IgG levels on these medications?
Do you just use antibiotic prophylaxis if therapy is started prior to meningococcal vaccination?
Based on this review (Melamed and Lee, PMID 31998289), patients with MS on several DMTs may be at higher risk for certain cancers. How does this play ...
For example, a GAD65 Ab of 0.07 when the cut-off is 0.02. Does this answer change if you consider adult vs pediatric populations?
Instead of waiting for the antibody test to result, if you have a high suspicion for NMDAR encephalitis, is there a role for giving rituximab alongsid...
What is the diagnostic yield and complication rate in your experience?
Do you wait for a second clinical event or start immunomodulatory therapy right away?
Specifically, what do you do if there is minimal improvement with IV steroids and/or IVIG?
Are there any specific patient populations that you are no longer routinely recommending to start B-cell depleting medications? For example, are you l...
Based on the results of the recent longitudinal analysis linking EBV infection and MS (Bjornevik et al., PMID 35025605), can negative EBV antibodies (...
For example, a clinically stable patient on eculizumab, do you continue it indefinitely?
Thoughts on sarilumab vs methotrexate, or just treat with steroids alone
Small study in pediatric PACNS have evaluated this as a potential marker (Cellucci et al., PMID 22740622)
If not, how often do you repeat pelvic imaging?
Do you approach things differently if a rare variant like this is suspected? Is the Balo's subtype more similar to RRMS or PPMS?
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Papers discussed in this category
Mult Scler, 2018 Feb
Neurology, 2020 Jul 29
Cells, 2018 Dec 28
Neurol Sci, 2015 Jun 25
World J Clin Cases,
Mult Scler Relat Disord, 2020 Dec 16
Archives of neurology, 2009-06
Muscle & nerve, 2013-04
Muscle & nerve, 2016-08
Muscle & nerve, 2017-07
Annals of neurology, 2017-07
Front Neurol, 2019 Jun 06
Neurology(R) neuroimmunology & neuroinflammation, 2017-07
J Med Life,
J Clin Neurol, 2018 Feb 28
Mult Scler, 2014 Mar 03
Mult Scler Relat Disord, 2016 Dec 23
N Engl J Med,
Lancet, 2016 Mar 04
Arthritis Rheum,
Journal of neurovirology, 2018-06
The Lancet. Neurology, 2013-06
Neurologic clinics, 2008-08
Neuroepidemiology, 2007 Sep 11
The Lancet. Neurology, 2014-02
The New England journal of medicine, 2017-01-19
N Engl J Med,
J Allergy Clin Immunol, 2022 Feb 14
Mult Scler Relat Disord, 2021 Sep 04
Muscle & nerve, 2007-01
Annals of neurology, 1990-03
Rheum Dis Clin North Am, 2017 Aug 23
Neurology,
Medicine (Baltimore),
Muscle Nerve, 2014 Dec 23
Archives of ophthalmology (Chicago, Ill. : 1960), 1988-08
Neurology, 2011-01-18
The Lancet. Neurology, 2016-04
Lancet Neurol, 2020 Nov 23
Clin Microbiol Infect, 2018 Feb 07
Neurology, 2021 Oct 05
Neurology, 2017-11-14
Neurol Neuroimmunol Neuroinflamm, 2020 Jul 27
Arthritis and rheumatism, 2009-11
Rheumatology (Oxford), 2014 Oct 21
Cureus, 2019 Aug 19
J Rheumatol, 2007 Sep 15
Rheumatol Int, 2007 Jul 20
Lupus, 2017 Feb 26