How do you manage a glioblastoma of the brainstem/upper cervical spinal cord?

It used to be that we didn’t get biopsies in this location, and we treated suspected astrocytic tumors in the brainstem/upper spinal cord to 54 Gy in 30 fractions without tissue. The outcome was never good. But now we generally have at least a stereotactic biopsy. The outcome is still not good of co...

I also agree with @Dr. First Last that it makes little sense to overemphasize low-risk toxicity when you are faced with an aggressive, unresectable tumor. Like @Dr. First Last, I think smaller volumes are fine in this situation. It is worth remembering that the ASTRO guideline lists a range of accep...