How do you manage a locally advanced hormone receptor-positive invasive ductal carcinoma with neuroendocrine (small cell) features?

The first thing is to determine if the cancer has small cell features or if it is an extra pulmonary small cell cancer. If it is a true small cell cancer it will have the appearance of small cell in addition to staining for neuroendocrine markers (chromogranin and synaptophysin). Work up would inclu...