How do you manage a patient with JAK2+ ET without history of thrombosis during pregnancy?

Great question. We've recently published our experience here How et al., PMID 33022566. Patients with ET that are pregnant and that don't have a history of thrombosis are likely to be in the very low/low risk categories by R-IPSET, many of these women are likely not on any treatment prior to startin...

I agree with what Dr. @Dr. First Last said. When a patient starts trying to get pregnant, I make sure to stop hydroxyurea, ruxolitinib, etc. If they require cytoreduction, (i.e., PV or high risk ET), I start pegylated interferon (Pegasys), at this point, I don't believe there is enough data availabl...