How do you manage a recurrent craniopharyngioma?

Complex answer—my personal view based on my Neurosurgery and SRS/RO experience:

1. If the recurrence is a single large cyst—surgery (stereotactic aspiration combined with SRS to collapsed cyst immediately, have done the same day) or Intra-cavitary P32.

2. If it's a small solid/micro-cystic recurrence—...

For patients with recurrent disease after radiotherapy, an alternative approach is systemic therapy. Recent studies have shown that 95% of papillary craniopharyngiomas have BRAF V600E mutations (Brastianos et al., Nature Genetics 2014). Several case reports have shown dramatic responses of craniopha...

If braf v600e is negative, I’ve done carbo/taxol or tmz and cape.