Harsh protracted esophagitis was reported in 4% of Int. O139(1999)i.e., grade 4 regardless of once or twice daily cycle 1 concurrent. CONVERT reports 18% grade 3!or higher, either QD 66 or BID 45. No reports of > 1 mo duration. Consider endoscopy and culture. Empiric carafate and anti-fungal/cand...

Sometimes herpes esophagitis can happen as a superinfection. Endoscopy is important to assess if there is an ulceration, so then intense anti-reflux medications and carafate can be prescribed.