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How do you manage de novo high volume mCSPC with both BRCA2 mutation and MSI-H on somatic testing?
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1 AnswersMednet Member
Medical Oncology · Duke University School of Medicine
This is a very rare but interesting scenario. Presumably in this case, the BRCA2 mutation is a passenger event in the setting of high TMB as a result of MMRD/MSI high disease, which has been reported. Typically these BRCA alterations are monoallelic and the tumors lack homologous repair deficiency a...