How do you manage disease progression during adjuvant chemoradiotherapy for glioblastoma?

Hospice.

I agree with @Dr. First Last. This is not a “single best answer” question.

First, I’ll pose a question of my own: do you check the “radical” or “palliative” box in your prescription? I have never had a patient achieve permanent NED status, so I view our role as aggressive palliation.

As @Dr. First L...

How are you defining disease progression during chemoradiation? If just radiographic, I would treat on. If clinical, I would consider transitioning to hypofrac (if not already doing so) and completing treatment.

If very early on in the course, and disease is resectable (say early recurrence between ...

As a clinical practice matter, I strongly doubt true progression during chemoradiation therapy and have no "stronger" treatment options that would be more cytocidal. I typically manage symptoms and proceed with the planned course of RT.

Radiographic progression during treatment is expected and reflec...