Topics:
Genitourinary Cancers • Prostate Cancer • Medical Oncology • Hematology • Benign Hematology • Anticoagulation
How do you manage drug-drug interactions between oral anticoagulants and the ARSI agents such as apalutamide and enzalutamide?
Answer from: Medical Oncologist at Academic Institution
Commonly used oral anticoagulants, such as apixaban, rivaroxaban, and warfarin are substrates of hepatic cytochrome P450 enzymes (CYP). Co-administration of an AR signaling inhibitor (ARSI) variably affects the concentration of those drugs depending on the effect on the type of CYP enzymes. For exam...
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