This is a real but uncommon side effect of Pluvicto therapy. Per VISION, it will happen in maybe 3% of patients but almost never high grade. Interestingly, the absorbed dose for the lacrimal glands is 2.1 Gy/Gbq - which over 6 cycles full dose at 7.4 GBq/200 mCi per cycle means 92 Gy. There was a me...

It is a pity that dosimetry was not performed in the VISION trial and therefore, we do not know the absorbed doses to the lacrimal glands in patients with or without dry eyes subsequently. A recently published small study revealed that the absorbed doses ranged from 55-100 Gy. (Herrmann et al., J Nu...