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How do you manage early stage I uterine serous carcinoma?

VC brachy, pelvic RT, +/- chemo? Does your management change if it is confined to the endometrium without myometrium invasion or if it is only a endometrial polyp?
3 Answers
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Radiation Oncology · University of Texas MD Anderson Cancer Center
Answered on

The management of these patients remains controversial. The data are conflicting and treatment choices tend to be based more on impressions than solid data. Most clinicians advocate chemotherapy although randomized trials have not clearly shown benefit for this subset. For stage IA, we typically tre...

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Radiation Oncology · Varian Medical Systems/Allegheny health network
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At present for surgically staged serous ca of endometrium, my philosophy is to treat like Grade 3 endometroid when deciding about radiation.

As far as chemo, most gyne oncs would give adjuvant chemo irrespective of stage, although the recent GOG 249 presentation did not see a benefit of chemo for st...

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Radiation Oncology · Mon Health
Answered on

Based on GOG 249, is it very reasonable to treat stage I or II uterine serous carcinomas, with negative peritoneal cytology, with pelvic radiation alone?

Thank you

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