How do you manage erythrocytosis secondary to sotatercept for patients with PAH?

Do you recommend phlebotomy (e.g., if Hct increases significantly above baseline or baseline Hct is elevated) or refer your patients to hematology?

Answer from: at Academic Institution

I have not done that yet, but I have let Hgb drift up to 18-19 and monitor the patient closely. I lower the dose to 0.5 or even 0.3, if Hgb is high at baseline, then start and stay at 0.3 before I increase. I will consider phlebotomy if the above options are not available.

Comments

Medical Oncologist at Los Angeles VA Medical Center
Very helpful Dr.@Parth Rali, thank you!

at Temple University Hospital
My pleasure.

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How do you manage erythrocytosis secondary to sotatercept for patients with PAH?

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