How do you manage Fanconi’s syndrome and polyuria related to ifosfamide?

Treatment of ifosfamide-induced Fanconi syndrome and polyuria is primarily supportive. First, the benefits and risks of discontinuation of ifosfamide should be discussed with the oncologist. Treatment of Fanconi syndrome is aimed at repletion of potassium, bicarbonate, and phosphate. Calcitriol is also administered to prevent and treat rickets in children or osteomalacia in adults. Potassium citrate can be used to treat both hypokalemia and proximal renal tubular acidosis (RTA).

The polyuria ass...