How do you manage maintenance for BRAF V600E-mutated metastatic colon cancer responding to FOLFOX + encorafenib + cetuximab (BREAKWATER) in the first line?

Do you continue oxaliplatin until toxicity or plan to stop after 6-8 cycles? Do you continue 5-FU until progression? Elez et al., PMID

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What is your preferred maintenance regimen in BRAF mutated metastatic colon cancer?

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2 Answers

Mednet MemberInvited Expert

Medical Oncology · Henry Ford Cancer Institute (HFCI)

Answered on · Updated on

I would treat with mFOLFOX plus encorafenib and cetuximab for 8-12 cycles, provided responding/tolerating, and then maintain on encorafenib and cetuximab without the 5-FU till progression/intolerance.

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Medical Oncology · University of Wisconsin

Answered on

Just like Dr. @Dr. First Last, I would usually continue encorafenib/cetuximab in the maintenance setting, after 4-6 mo of FOLFOX, as peripheral neuropathy and chemo tolerance permit.

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