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How do you manage maintenance for BRAF V600E-mutated metastatic colon cancer responding to FOLFOX + encorafenib + cetuximab (BREAKWATER) in the first line?
Do you continue oxaliplatin until toxicity or plan to stop after 6-8 cycles? Do you continue 5-FU until progression?
Answer from: Medical Oncologist at Community Practice
I would treat with mFOLFOX plus encorafenib and cetuximab for 8-12 cycles, provided responding/tolerating, and then maintain on encorafenib and cetuximab without the 5-FU till progression/intolerance.
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