How do you manage maintenance for BRAF V600E-mutated metastatic colon cancer responding to FOLFOX + encorafenib + cetuximab (BREAKWATER) in the first line?

I would treat with mFOLFOX plus encorafenib and cetuximab for 8-12 cycles, provided responding/tolerating, and then maintain on encorafenib and cetuximab without the 5-FU till progression/intolerance.

Just like Dr. @Dr. First Last, I would usually continue encorafenib/cetuximab in the maintenance setting, after 4-6 mo of FOLFOX, as peripheral neuropathy and chemo tolerance permit.