Topics:
Pediatric Oncology • Rhabdomyosarcoma
How do you manage newly diagnosed stage IV embryonal rhabdomyosarcoma?
Parameningeal disease with distant metastatic deposits to lymph nodes and lungs, fusion negative. What are the considerations for cyclophosphamide dosing?
Answer from: at Academic Institution
Given stage 4 FOX01- RMS, I think you can either use protocol ARST0431 which has 10.8g/m2 (>4y) or 360 mg/kg (<4y) of CPM, or ARST1431 (8.4g/m2) since cumulative CPM dosing is not that much different. I do not dose modify CPM based on the primary site.
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Answer from: at Community Practice
In my opinion, stage 4 group IV fusion negative (embryonal) rhabdomyosarcoma is a challenge right now. It is considered intermediate-risk currently but has bounced between high-risk and intermediate-risk on the last couple of protocols. My personal interpretation of the literature is that using VAC/...
Comments
at Roswell Park Cancer Institute
Thank you, Joanne and Joel, for your thoughtful an...
Thank you, Joanne and Joel, for your thoughtful an...
at Children's Mercy Hospitals and Clinics
Interesting--I had not seen these data. I'm ...
Interesting--I had not seen these data. I'm ...