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How do you manage patients with bipolar I disorder who report emotional blunting or numbness while taking lithium?

Some patients taking lithium describe feeling emotionally flat or numb, which can lead them to question whether the medication is worth continuing, even when it has been effective in preventing manic episodes. How do you talk with patients about emotional blunting and address concerns about losing access to positive emotions? How do you navigate patient ambivalence about preventing mania, particularly when patients remember manic or hypomanic states as productive, exciting, or pleasurable? What medication adjustments, if any, do you consider?
1 Answer
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Psychiatry · Perelman School of Medicine, University of Pennsylvania
Answered on

Adjusting the once-daily bedtime dose to a lower level in the therapeutic range may help. I always tell patients that this is a recognized side effect of lithium. A discussion about the often unavoidable depressive episode following a manic episode may convince patients that avoiding a manic or hypo...

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