How do you manage patients with severe HSV disease who develop significant nephrotoxicity on IV acyclovir?

I would usually continue acyclovir with slower infusion rates of at least 1 hour and pre- and post-infusion hydration as well as engaging pharmacy to really dose-adjust the medication. Renal toxicity is hardly ever a reason to not use IV acyclovir in severe HSV disease. The alternatives cidofovir an...