How do you manage patients with suspected cholangiocarcinoma that presents with biliary obstruction but has repeated negative brushings/biopsies?
Is liquid biopsy helpful? Would you treat if this shows somatic mutation?
Answer from: Medical Oncologist at Community Practice
Agree with Dr. @Tran's answer. This specific scenario here likely describes non metastatic perihilar or distal cholangiocarcinoma. The first thing is to ensure advanced endoscopic attempts have been exhausted including spyglass-directed biopsy, etc.
As Dr. Tran indicated, frequently occurs in...
In non-PSC patients who cannot get upfront surgery...