How do you manage PBC patients who achieve a biochemical response on second-line therapy but show worsening noninvasive markers of portal hypertension or fibrosis over the following year (e.g., rising liver stiffness and falling platelets)?
1 Answer
Mednet MemberInvited Expert
Hepatology · Johns Hopkins Medicine
Answered on
If a patient is getting worse on second line therapy, I would confirm worsening fibrosis with 2 modalities and then probably stop the second liver therapy.
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