How do you manage platelet transfusion refractoriness in a patient with severe aplastic anemia?

- How do you manage this platelet transfusion refractoriness in a patient with aplastic anemia prior to performing hematopoietic stem cell transplant? - Is platelet transfusion refractoriness in severe aplastic anemia a big risk for hematopoietic stem cell transplant engraftment failure? - How do you manage this platelet transfusion refractoriness in a patient with aplastic anemia especially in the setting of no matched sibling or unrelated donor and considering IST is the option (As ATG also leads to platelet consumption)?