How do you manage polyuria and polydipsia from lithium?  

Amiloride 5 mg will do the trick for most patients. Make sure you are around 0.75, using IR Li, all at night.

My first step is to confirm that the symptoms, including polydipsia and polyuria, are due to NDI and not other reasons. Other potential causes that should be excluded are: Psychogenic polydipsia other substance-induced, such as caffeine, diuretics primary DM pituitary related CKD Lowering ...