How do you manage radiotherapy for a glioblastoma when there is a delay in starting systemic therapy?

It depends on whether we are discussing a post op vs unresectable patient.

It is okay to delay in post op imo up to 4-6 weeks out after a GTR. I would not start within 2 weeks after biopsy, regardless of temodar authorization in an unresectable patient.

Blumenthal et al., PMID 19114694