How do you manage reactive thrombocytosis and potentially symptomatic fatigue from JAK2+ P Vera with iron deficiency?
Bone marrow biopsy showed absent stainable iron. JAK2+ PV can sometimes present with reactive thrombocytosis if very iron deficient. Do you restore iron and cytoreduce simultaneously?
1 Answer
Mednet MemberInvited Expert
Hematology · Icahn School of Medicine at Mount Sinai/Mount Sinai Hospital
Answered on
This is a challenging scenario since if you start supplementing iron, you can increase erythropoiesis, raise the hematocrit, require more therapeutic phlebotomies, and end up chasing your own tail. For these reasons, I generally recommend against iron supplementation in PV.
Regarding the fatigue and...
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