How do you manage recurrent inoperable chest wall pleomorphic liposarcoma with prior radiation therapy?

Palliatively. But review the case and see if anything could be done differently next time. Local control of STS with proper surgery and radiation should be excellent. Perhaps there was a positive surgical margin that should have been re-resected, perhaps postop RT wasn't properly designed, etc. With...

Several things are notable about this case

1. Medically inoperable 2 years after GTR. The patient must have had some issues at the time of original surgery.
2. How much time between surg and the start of radiation?
3. Any CTX at original TX.
4. Location of tumor, OAR doses, radiation technique.

These items ...