How do you manage resistant infections that persist after stopping antibiotic therapy in patients with non-CF bronchiectasis?

In patients with non-CF bronchiectasis who continue to have infections after completing antibiotics, I first obtain repeat sputum cultures to identify the organism and check for any resistance patterns. I also review adherence to airway clearance techniques, as inadequate mucus clearance often contr...

It depends on what is meant by resistant infections; if this means multi-drug resistant bacteria that remain present after treatment ends and when symptoms have returned to baseline, there are many things to consider. First, has the person had many exacerbations before? Or do they have minimal sympt...

Ultimately depends on the why and where

WHY has the organism acquired resistance genomes? (Too much) Prior Abx exposures? Resident in a unit (NH, Chronic Care, ICU) with high ambient MDR’s? Warranted or inadvertent elimination of protective normal flora? Usually, a combination of several.

WHERE is t...