How do you manage symptomatic fat necrosis following adjuvant breast radiotherapy?  

If the diagnosis of fat necrosis is not in doubt (i.e., recurrence has been ruled out) and is not getting better: You can start with NSAIDS, warm compresses, a supportive bra, and massage therapy. Then, I'd consider steroids, though evidence is limited, Prednisone 20 mg for a week or so. Some p...