How do you manage toxicities in patients with mPDAC receiving daraxonrasib?

In our experience, we have found several strategies effective:

• Rash: Doxycycline 100 mg twice daily, avoid all sun exposure and use sunscreen, apply hydrocortisone 2.5% twice daily to face and upper chest and back and neck apply emollient moisturizer to arms, legs, hands, feet at least twice daily....