How do you mitigate 6-MP-induced GI toxicity in pediatric and AYA patients with leukemia?
Answer from: at Academic Institution
This is a great question as GI toxicities are commonly encountered in children, adolescents, and young adults being treated with 6MP including elevated transaminases, pancreatitis, and hypoglycemia. These GI toxicities are likely due to a skewing of 6MP metabolites with an accumulation of the GI tox...
Sign in or Register to read more
Answer from: at Academic Institution
I agree with Dr. @Rau's answer and have used allopurinol with reduced dose mercaptopurine in several patients with unacceptable GI toxicity, with good results.That being said, I have always wondered what we know about the leukemia outcome for such patients. In the NOPHO group, they have done extensi...
Comments
at Seattle Children's Hospital, University of Washington
Great points!!
Great points!!
at University of Missouri Health Care
Thank you! I have a patient with recurrent pancrea...
Thank you! I have a patient with recurrent pancrea...
at Rainbow Babies and Children's Hosp/Case Western Reserve Univ
Was this patient tested for genetic mutations for ...
Was this patient tested for genetic mutations for ...