How do you now approach treatment sequencing in MM in light of the DETERMINATION trial data?
Do the results change your clinical practice?
Community PollStarted
Has the DETERMINATION trial impacted your use of transplant in MM?
39 physicians have voted
Join Mednetto vote and see how they answered.
2 Answers
Mednet MemberInvited Expert
Medical Oncology · University of Chicago
Answered on
There are two questions that come to mind re: DETERMINATION with respect to sequencing.
1) To do early transplant or not?
2) To do indefinite lenalidomide maintenance?
My views on question #1 are evolving, but here is how I have unpacked it and stated elsewhere on theMednet.
REASONS TO DO TRANSPLANT:
- ...
Join for free or sign in to see the full answer
Mednet MemberInvited Expert
Medical Oncology · Winship Cancer Institute of Emory University
Answered on
The DETERMINATION trial is the U.S. half of the IFM-DFCI 2009 trial - the results from the French patients with fixed duration of Revlimid maintenance have already been published. Since I already continue maintenance until toxicity or resistance, DETERMINATION didn't change my practice.
On the other...
Join for free or sign in to see the full answer