How do you prevent hyponatremia in a patient with arginine vasopressin deficiency on chronic desmopressin?

Adequate instruction is very important in order to minimize the risk of hyponatremia in patients with AVP-D (central DI). Patients need to understand that, rather than taking desmopressin on a fixed schedule, it is very important to allow the medication to wear off for at least 30 minutes once a day...