How do you prioritize treatment in a lung cancer patient who has HER2 IHC3+ along with other actionable mutations that have tumor-specific drugs available?

Would you sequence tumor-specific treatments first? Where would you sequence non-targeted standard chemotherapy or immunotherapy?

Answer from: Medical Oncologist at Community Practice

Non-small cell lung cancer (NSCLC) can harbor different HER2 alterations: HER2 protein overexpression (2-35%), HER2 gene amplification (2-20%), and HER2 gene mutations (1-4%). Unlike breast or gastric cancer, HER2 protein overexpression in NSCLC is not a validated biomarker for first-line HER2-targe...

Answer from: Medical Oncologist at Academic Institution

For all cancers, it is important to balance the expected antitumor activity of agents with tumor-specific approvals as well as adverse event profiles to personalize treatment choice and sequence of therapies.

Please select the option that best describes you:

How do you prioritize treatment in a lung cancer patient who has HER2 IHC3+ along with other actionable mutations that have tumor-specific drugs available?

Related Questions