How do you recommend mitigating the risks of using beta blocker and clonidine therapy in combination for management of hypertension?

Beta blockers vary in lipophilicity, which affects blood-brain barrier permeability. Propranolol and metoprolol readily cross the blood-brain barrier, while other beta-blockers like nebivolol do not. The CNS side effects of fatigue, depression, and insomnia are more likely to worsen if using a lipop...

Sometimes both are indicated. Simply do a 3 day Zio monitor to exclude significant bradycardia.