How do you reconcile the benefits of high glycemic load to slow ALS disease progression with previous data on the increased risk for ALS associated with diabetes mellitus?

The relationship between diabetes and ALS is still controversial and poorly understood. Several recent studies, including observational studies in the general population, and Mendelian randomization studies, indicate that type 2 diabetes is associated with a decreased risk of ALS, especially in olde...

This is indeed an important topic that needs more well-designed studies among different age and race groups. In the referenced article (Vasta et al., Neurological Sciences 2021.), Vasta and colleagues reviewed previous studies on the link between diabetes mellitus and ALS. Among 9 studies that asses...