How do you select an SSRI and dosing strategy for older adults newly being treated for depression?

SSRIs are preferred based on tolerability, drug interaction potential, and comorbidities. Start at low doses (e.g., sertraline 25 mg daily) and titrate gradually to therapeutic levels over 1–2 weeks, monitoring closely for adverse effects.

Among SSRIs, sertraline and escitalopram are particularly r...